CINCHONINE MONOHYDROCHLORIDE HYDRATE
cinchonine monohydrochloride hydrate
CAS: 5949-11-1
Molecular Formula: C19H23ClN2O
CINCHONINE MONOHYDROCHLORIDE HYDRATE - Names and Identifiers
| Name | cinchonine monohydrochloride hydrate |
| Synonyms | Cinchonine monohydro CINCHONINE HYDROCHLORIDE cinchonine,monohydrochloride CINCHODININE DIHYDROCHLORIDE CINCHONINE HYDROCHLORIDE N-HYDRATE cinchonine monohydrochloride hydrate monohydrochloride,(9s)-cinchonan-9-o (+)-CINCHONINE HYDROCHLORIDE N-HYDRATE (3alpha,8alpha,9R)-cinchonan-1-ium-9-ol (S)-Quinolin-4-yl((1S,2R,4S,5R)-5-vinylquinuclidin-2-yl)methanol hydrochloride |
| CAS | 5949-11-1 |
| EINECS | 621-239-2 |
| InChI | InChI=1/C19H22N2O/c1-2-13-12-21-10-8-14(13)11-18(21)19(22)16-7-9-20-17-6-4-3-5-15(16)17/h2-7,9,13-14,18-19,22H,1,8,10-12H2/p+1/t13-,14+,18+,19-/m1/s1 |
CINCHONINE MONOHYDROCHLORIDE HYDRATE - Physico-chemical Properties
| Molecular Formula | C19H23ClN2O |
| Molar Mass | 330.85 |
| Melting Point | 208-218°C(lit.) |
| Boling Point | 464.5°C at 760 mmHg |
| Specific Rotation(α) | 182° (C=1,EtOH) |
| Flash Point | 234.7°C |
| Solubility | Dissolution and mixing in combustible solvents |
| Vapor Presure | 1.99E-09mmHg at 25°C |
| Appearance | Powder |
| Storage Condition | under inert gas (nitrogen or Argon) at 2-8°C |
| MDL | MFCD00079070 |
CINCHONINE MONOHYDROCHLORIDE HYDRATE - Risk and Safety
| Risk Codes | R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed. R36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S36/37 - Wear suitable protective clothing and gloves. S36 - Wear suitable protective clothing. S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. |
| UN IDs | 1544 |
| WGK Germany | 3 |
| RTECS | GD2962020 |
| FLUKA BRAND F CODES | 8 |
| Hazard Class | 6.1(b) |
| Packing Group | III |
CINCHONINE MONOHYDROCHLORIDE HYDRATE - Reference Information
| overview | cinkoning is a naturally formed substance extracted from cinchona bark and is a member of the alkaloid family. Cinkonin has an inhibitory effect on the MDR phenomenon. It can be used to prepare pharmaceutical compositions for the treatment of cancer tumors with MDR phenomenon. After research, it is found that the salt of cinkoning, cinkoning hydrochloride not only has the required solubility and bioavailability standards for pharmaceutical preparations, but also retains the required therapeutic properties, and it is in the solution It is also very stable, which is beneficial to the preparation of aqueous preparations, especially in the form of injectable preparations. |
| action and use | cinkonin hydrochloride can be used as an inhibitor of "multi-drug resistance" (MDR) phenomenon. In particular, cincorine hydrochloride compositions can be used to treat cancer-related diseases with MDR phenomena. if the known conventional drug resistance, the composition can also be used as an antispasmodic substance, used to treat arrhythmia, can also be used to treat malaria. MDR phenomenon is known to be particularly related to cancer. But it also occurs in other diseases such as malaria. On the one hand, cancer has congenital MDR. On the other hand, cancer is treated with anticancer drugs, especially anthracycline antibiotics. The MDR phenomenon associated with cancer can inhibit the cytotoxicity of some anti-tumor drugs, or even make the drugs ineffective. |
| biological activity | Cinchonine hydrochloride ((8R,9S)-Cinchonine hydrochloride) is a natural compound in cinchona bark and has antimalarial activity. Cinchonine hydrochloride can activate endoplasmic reticulum stress to induce apoptosis of human liver cancer cells. |
Last Update：2024-04-09 15:16:38
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Multiple Specifications
Product Name: Cinchonine hydrochloride Visit Supplier Webpage Request for quotationCAS: 5949-11-1
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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